Palmoplantar pustulosis secondary to rituximab: A tool to help to better discern potential causal drug relations is the Naranjo adverse drug reaction probability scale. For permission for commercial use of this work, please see paragraphs 4. The cooccurence of rheumatoid arthritis and psoriasis of the skin in the same patient is rare. How to cite this article:

Severe pustular psoriasis provoked by oral terbinafine. The development of this so-called paradoxal psoriasis — given that TNF-alpha antagonists are applied as biological treatment for psoriasis — is well-documented for nondermatological indications of anti-TNF-alpha antagonism, such as inflammatory bowel disease and rheumatoid arthritis. Recognized side effects include immune-mediated toxicity, such as the development of psoriasis. The proinflammatory cytokine interferon-alpha produced by plasmacytoid dendritic cells might be implicated. Traditionally, there have been strong associations documented for beta-blockers, lithium, synthetic antimalarial drugs, interferons, imiquimod, and terbinafine Table 3. Wilson NJ, Evans S. Waqar S, Sarkar PK.

Alternatively, surveillance bias may underlie the increased drug utilization among patients with psoriasis. Her skin eruptions improved, but her joint disease flared.

Drug-induced psoriasis: clinical perspectives

There are several ways in which a drug can affect psoriasis Table 1. However, in clinical practice, identifying medication-related exacerbations and induction of psoriasis can be challenging.

Assessment with the Naranjo scale could be helpful for clinical practice to strengthen a possible drug association. However, there is mounting evidence that a key innate immune pathway for triggering common human autoimmune disease involves plasmacytoid dendritic cell precursors PDCs and type 1 interferon IFN production.

Paraffin-embedded sections palmpplantar deparaffinized and stained with standard hematoxylin-eosin. Cutaneous eruptions were controlled with topical corticosteroid treatment alone or in combination with salicylic acid or calcipotriol in 18 patients data unavailable for 25 patients.


palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

There have been documented cases of generalized psoriasis and erythrodermic psoriasis, requiring hospitalization for proper management. Exposure to certain drugs can elicit an induction or exacerbation of psoriasis.

Waqar S, Sarkar PK. acse

reeview For instance, psoriasiform skin lesions may miss well-demarcated borders or lack the coarse scaling typical of psoriasis. In this regard, 1 of our patients patient 7 had both a psoriasiform eruption and evidence of lupuslike autoimmunity. VEGF antagonists such as sorafenib, a small molecule inhibitor, have been reported in case reports and case series of psoriasis induction and exacerbation. The etiology of psoriasis is multifaceted.

palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

Nine of the 15 patients had pustular lesions on their palms and soles. Exposure to certain medications can either induce or exacerbate psoriasis.

palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

Increased sensitivity to interferon-alpha in psoriatic T cells. However, in some cases, so-called psoriasiform skin lesions are described. The list of drugs that have associations with drug-related psoriasis is quite extensive. Psoriasis has been described predominantly in patients with hepatitis C 214647 but also infrequently in patients with melanoma, 48 leukemia, 4950 Kaposi sarcoma, and renal cell carcinoma.

Create a personal account to register for email alerts with links to free full-text articles. Several drugs have a well-described mode of action by which they can induce the development of psoriasis.

Palmoplantar pustular psoriasis induced by adalimumab: a case report and literature review.

Onset of psoriasis upon interferon beta treatment in a multiple sclerosis patient. Our recommendation is for the patients to be controlled with potent topical corticosteroids, keratolytics, Vitamin D analogs, phototherapy, increases in baseline methotrexate doses, and cyclosporine as needed.


Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: Paradoxical exacerbation of chronic plaque psoriasis by sorafenib. How to cite this article: Other clinical presentations included guttate or plaque psoriasis on the trunk and extremities, flexural psoriasis, scalp psoriasis, and nail disease. Medikamenteninduzierter Lupus erythematodes und Triggerung psoriatischer Hautveranderungen.

Palmoplantar pustular psoriasis induced by adalimumab: a case report and literature review.

Advanced Search Litedature Online: Upon discontinuation of the implicated drug, the psoriasis exacerbation can decrease ie, drug-induced psoriasis. For some medications such as lithium, beta-blockers, and imiquimod, a direct drug effect is suspected. Female sex and smoking were more frequently associated with TNF-alpha inhibitor-induced psoriasis.

The development of psoriasis of the skin in a patient with a rheumatologic disease does not necessarily mean that a misdiagnosis of the rheumatologic condition has been xnd. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more.

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